Dr. Mohammad Uddin

Associate Professor of Pharmaceutical Sciences

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Uddin

Education

B.S., Jahangirnagar University, Dhaka, Bangladesh
M.S., Jahangirnagar University, Dhaka, Bangladesh
M.S., Emory University
Ph.D., Mercer University

Research Interests

My research interest focuses on developing a quickly soluble film-based delivery system to deliver small molecule drugs or vaccines via buccal or sublingual administration. My research seeks to develop highly efficient, cost-effective and patient-compliant film dosage forms of vaccines for cervical cancer. Film-based vaccines are prepared using bio-degradable, bio-compatible and non-antigenic polymers. Then the physicochemical properties such as solubility, endurance, tensile strength, thickness, etc. of the film are determined and then ensued by an in vitro dissolution study and in vivo animal study to evaluate the efficacy of the formulation.

Courses

PHA 337 Biopharmaceutics and Pharmacokinetics
PHA 338 Pharmaceutics and Medicinal Chemistry
PHA 375 Comprehensive Patient-Centered Care
PHA 529 Contemporary Compounding
PHA 538 Basic and Clinical Sciences Review
PHA 715 Pharmacokinetics
PHA 742 Foundation of Pharmaceutical Science

Potential Application of Ionic Liquid 1,4-Diazabicyclo-Octane for Enhanced Buccal Permeability of Diphenhydramine Hydrochloride in Oral Dissolving Polymeric Film. Hayley Harrod, Sarthak M Shah, Safa Ahmed, Rawas-Qalaji Mutasem, Mohsin Kazi, Babak Minofar, Samir A Kouzi and Mohammad N Uddin*, EC Pharmacology and Toxicology. 11.6 (2023): 01-16.
Potential of DPD ((S)-4,5-dihydroxy-2,3-pentanedione) Analogs in Microparticulate Formulation as Vaccine Adjuvants. Devyani Joshi, Sarthak Shah, Christiane Chbib, and Mohammad N. Uddin*. Pharmaceuticals 2024, 17, 184. https://doi.org/10.3390/ph17020184.
Immune responses induced by Adjuvanted-Spike protein-based Microparticulate Vaccine delivered by Dissolving Microneedles against SARS-CoV-2. Smital Patil, Sharon Vijayanand, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Shadi Yacoub, Mohammad N. Uddin*, and Martin J. D’Souza*. Pharmaceuticals 2023, 16, 1131. https://doi.org/10.3390/ph16081131
Evaluation of the in vitro release of different commercial oral modified niacin formulations intended to reduce cutaneous flushing and hepatotoxicity adverse events. Christiane Chbib*, Sarthak Shah, Mohsin Kazi, Mohammad N. Uddin*. Polymers 2023, 15,3046.
Amikacin-Loaded Chitosan hydrogel Film crosslinked with folic acid for Wound Healing Application- Yasir Mehmood *, Hira Shahid, Numera Arshad, Akhtar Rasul, Talha Jamshaid, Muhammad Jamshaid, Usama Jamshaid, Mohammad N. Uddin, Mohsin Kazi *. Gels 2023, 9, 551. https://doi.org/10.3390/gels9070551.
Vaccine-Induced Immunity Elicited by Microneedle Delivery of Influenza Ectodomain Matrix Protein 2 Virus-like Particle (M2eVLP)-Loaded PLGA Nanoparticles. Keegan Braz Gomes, Sharon Vijayanand, Priyal Bagwe, Ipshita Menon, Akanksha Kale, Smital Patil, Sang-Moo Kang, Mohammad N. Uddin and Martin J. D’Souza*. Int. J. Mol. Sci. 2023, 24, 10612. https://doi.org/10.3390/ijms241310612 | https://www.mdpi.com/journal/ijms
The Autoinducer N-Octanoyl-L-Homoserine Lactone (C8-HSL) as a Potential Adjuvant in Vaccine Formulations. Sarthak M. Shah, Devyani Joshi, Christiane Chbib, Monzurul A. Roni and Mohammad N. Uddin*, Pharmaceuticals 2023, 16, 713. https://doi.org/10.3390/ph16050713.
An Adjuvanted Inactivated SARS-CoV-2 Microparticulate Vaccine Delivered Using Microneedles Induces a Robust Immune Response in Vaccinated Mice. Sharon Vijayanand, Smital Patil, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Mohammad N. Uddin, Susu M. Zughaier* and Martin J. D’Souza. Pharmaceutics 2023, 15, 895. https://doi.org/10.3390/pharmaceutics15030895
Zika Vaccine Microparticles (MPs)-Loaded Dissolving Microneedles (MNs) Elicit a Significant Immune Response in a Pre-Clinical Murine Model. Akanksha Kale, Devyani Joshi, Ipshita Menon, Priyal Bagwe, Smital Patil, Sharon Vijayanand, Keegan Braz Gomes, Mohammad N. Uddin* and Martin J. D’Souza*, Vaccines 2023, 11, 583. https://doi.org/10.3390/vaccines11030583.
Subunit microparticulate vaccine delivery using microneedles trigger significant SARS-spike-specific humoral and cellular responses in a preclinical murine model. Smital Patil, Sharon Vijayanand, Devyani Joshi, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Shadi Yacoub, Mohammad N. Uddin, Martin J. D’Souza*. International Journal of Pharmaceutics 632 (2023) 122583
PLGA-Based Nanomedicine: History of Advancement and Development in Clinical Applications of Multiple Diseases. Hashem O. Alsaab,* Fatima D. Alharbi, Alanoud S. Alhibs, Nouf B. Alanazi, Bayan Y. Alshehri, Marwa A. Saleh, Fahad S. Alshehri, Majed A. Algarni, Turki Almugaiteeb, Mohammad N. Uddin and Rami M. Alzhrani. Pharmaceutics 2022, 14, 2728. https://doi.org/10.3390/pharmaceutics14122728
Enhanced immunogenicity of virus like particle (VLP) based HPV16 vaccines in microparticulate form with addition of adjuvant via transdermal route. Trinh Phuong Vo, Gitika Panicker, Kimberly Braz-Gomes, Ashwin Parenky, Ira Rajbhandari, Rajeevan Mangalathu, Elizabeth Unger, Martin D’Souza, Mohammad N. Uddin*. Pharmaceuticals 2022, 15, 1128. https://doi.org/10.3390/ph15091128.
Microneedle delivery of an adjuvanted microparticulate vaccine Induces high antibody levels in mice Vaccinated against Coronavirus. Sharon Vijayanand, Smital Patil, Devyani Joshi, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Priyal Bagwe, Shadi Yacoub, Mohammad N. Uddin and Martin J. D’Souza. Vaccines 2022, 10, 1491. https://doi.org/10.3390/vaccines10091491.
Potential application of microparticulate-based bacterial Outer Membrane Vesicles (OMV) vaccine platform to prevent Sexually Transmitted Diseases (STDs): Gonorrhea, Chlamydia, and Syphilis. Christiane Chbib, Sarthak M. Shah, Rikhav P. Gala, Mohammad N. Uddin*. Vaccines (Basel) 2021 Oct 27;9(11):1245. doi: 10.3390/vaccines9111245.
A Review on Current COVID-19 Vaccines and Evaluation of Particulate Vaccine Delivery Systems. Sarthak M. Shah, Hashem O. Alsaab, Mutasem M. Rawas-Qalaji and Mohammad N. Uddin*. Vaccines 2021, 9, 1086. https://doi.org/10.3390/vaccines9101086.
Challenges of Storage and Stability of mRNA-Based COVID-19 Vaccines. Mohammad N. Uddin*.; Roni, M.A. Vaccines 2021, 9, 1033.
Evaluation of Microparticulate (S)-4,5-Dihydroxy-2,3-pentanedione (DPD) as a Potential Vaccine Adjuvant –Devyani Joshi, Christiane Chbib, Mohammad N Uddin, Martin J D’Souza. AAPS J. 2021 Jun 15;23(4):84. doi: 10.1208/s12248-021-00617-6
Microneedles: A New Generation Vaccine Delivery System – Ipshita Menon, Priyal Bagwe, Keegan Braz Gomes, Lotika Bajaj, Rikhav Gala, Mohammad N. Uddin, Martin J. D’Souza and Susu M. Zughaier. Micromachines 2021, 12, 435. https://doi.org/10.3390/mi12040435
The Possible Relationship between the Abuse of Tobacco, Opioid, or Alcohol with COVID-19 – Yusuf S. Althobaiti, Maram A. Alzahrani, Norah A. Alsharif, Nawal S. Alrobaie, Hashem O. Alsaab and Mohammad N. Uddin. Healthcare 2021, 9, 2. https://dx.doi.org/10.3390/healthcare9010002.
Exploring the Potential of T Cells for a Universal Influenza Vaccine – Sharon Vijayanand, Keegan Braz Gomes, Rikhav P. Gala, Mohammad N. Uddin, and Martin J. D’Souza. Vaccines 2020, 8, 598; doi:10.3390/vaccines8040598.
Uddin MN, Basak D, Hopefl R and Minofar B. Potential application of ionic liquids (ILs) in pharmaceutical dosage form for vaccine and small molecule drug delivery system – Journal of Pharmacy & Pharmaceutical Sciences, 23(1), 158-176. 2019. https://doi.org/10.18433/jpps30965
Uddin MN, Henry B, Carter KD, Roni MA, and Kouzi, SA. A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine – J Pharm Pharm Sci (www.cspsCanada.org) 22: 536 – 547, 2019.
Uddin MN, Allon A, Roni MA, Kouzi S – Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines – J Pharm Pharm Sci, (www.cspsCanada.org) 22: 388 – 406, 2019.
Kouzi SA, Nicholas JD, Wright, Amie JD, and Uddin MN – Fumonisins: Mechanisms of Action and Effects on Human and Animal Health – EC Pharmacology and Toxicology, 6 (4): 187-208, 2018.
Uddin MN, Cotta KI and D’Souza MJ – Stability determination and evaluation of gamma irradiated nuclear-factor-kB antisense microsphere – Journal of Drug Design Development and Therapy, (DOI: 10.15406/mojddt.2016.01.00001) 1(1): 1-6, 2016
Uddin MN, Patel NJ, Bhowmik T, D’Souza B, Akalkotkar A, Etzlar F, Oettinger CW, D’Souza MJ. (2013). Enhanced bioavailability of orally administered antisense oligonucleotide to nuclear factor kappa B mRNA after microencapsulation with albumin. J Drug Target. 21(5):450-7.
Bhowmik, T, D’Souza B., Uddin MN and D’Souza M.J., (2012) Oral delivery of microparticles containing plasmid DNA encoding hepatitis-B surface antigen. J Drug Target, 20, 364-71.
D’Souza B, Bhowmik T, Uddin MN, Oettinger C, D’Souza M. (2015). Development of cyclodextrin-based sustained release microparticles for oral insulin delivery. Drug Dev Ind. Pharm. Aug;41(8):1288-93.
D’Souza B, Bhowmik T, Uddin MN, Oettinger C, and D’Souza MJ -Development of b-cyclodextrin-based sustained release microparticles for oral insulin delivery- Drug Development and Industrial Pharmacy, 41(8): 1288-1293, 2015.
Patel NJ, Addo R, Uddin MN, D’Souza MJ, and Jobe L. – The effect of antisense to NF-kB in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats. Journal of Drug Targeting, 3: 1-9, 2014.
Panicker G, Vo T, Rajvandari I, Uddin MN, Mangalathu R, Unger ER, and D’Souza MJ – Development of a microparticulate HPV vaccine for oral delivery. Supplement, The FASEB Journal, 27(1): 2013.
Etzler FM and Uddin MN – Powder Technology and Pharmaceutical Development: Particle Size and Particle Adhesion- Powder and Particle Journal, 30, 125-143, 2013.
Uddin MN, Oettinger CW, Bhowmik T, D’Souza B and D’Souza MJ – Enhanced bioavailability of Antisense to NF-ĸB Oligonucleotides after microencapsulation. Journal of Drug Targeting, 21(5): 450-457, 2013.
Uddin MN, Siddiq A, Oettinger CW, and D’Souza MJ – Potentiation of Pro- inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis. Journal of Drug Targeting, 2011 Nov; 19(9):752-60.
Siwale RC, Oettinger CW, Pai SB, Addo R, Uddin MN, Siddig A, D’Souza MJ – Formulation and characterization of Catalase in albumin microspheres. Journal of Microencapsulation, 24 (4): 337-348, 2009.
Uddin MN, Duc P. Do, Pai SB, Gayakwad S, Oettinger CW and D’Souza MJ – A Methodology for Quantitation and Characterization of Oligonucleotides in Albumin Microspheres. The Analyst, 134(7): 1483-1492, 2009.
Bhowmik T, Uddin MN, D’Souza B and D’Souza MJ – Oral Delivery of Microparticles containing Plasmid DNA encoding Hepatitis B Surface Antigen- Journal of drug Targeting, 20(4): 364-71, 2012.
Hagen KS and Uddin MN– A Continuous Symmetry Measure of [4Fe-4S]⁺ core distortions and analysis of supramolecular synthons in crystal structures of (Et₄N)₃[Fe₄S₄Cl₄]•Et₄NCl at 100 & 295K. Inorganic Chemistry, 47(24): 11807-11815, 2008.
Janiak C, Chamayou AC, Uddin AKM, Uddin MN, Hagen KS and Enamullah M- Polymorphs, enantiomorphs, chirality and helicity in [Rh{N,O}(.4-cod)] complexes with {N,O} = salicylaldiminato Schiff base or aminocarboxylato ligands. Dalton Transaction, 19: 3698-3709, 2009.
Enamullah M, Uddin AKM and Uddin MN, – Synthesis and spectroscopic characterization of Rh(I)-1,5-cyclooctadiene complexes containing the o-aminobenzoic acid or o-aminophenol as co-ligands. J. Bangladesh Chem. Soc., 21 (1): 28-35, 2008.
Enamullah M, Uddin MN and Linert W – Synthetic and spectroscopic characterization of Rh(I)-(S)-amino acid complexes with diphosphine and triphosphine ligands. – Journal of Coordination Chemistry. 60 (21): 2309-2318, 2007.
Enamullah M, Kabir M, and Uddin MN – Spectroscopic studies of the low -spin neutral Iron(II) -complexes with deprotonated. 4-X-2,6-bis(benzimidazol-2’yl)pyridine (X = H, OH and Cl). Journal of Bangladesh Chemical Society, 20(2): 163-171, 2007

Contact Dr. Mohammad Uddin

Moye Pharmacy and Health Sciences Center, #275
(678) 547-6224
uddin_mn@mercer.edu