Dr. Mahavir Chougule

Associate Professor of Pharmaceutical Sciences

Dr. Mahavir ChouguleEducation

Dr. Chougule’s C.V.

Courses

  • PHA 527 Biotechnology
  • PHA 548 Project Development
  • PHA 549 Introduction to Research
  • PHA 742 Foundations in Pharmaceutical Sciences
  • PHA 743 Foundations in Research
  • PHA 807 Pharmaceutical Biotechnology

Research Interests

Dr. Chougule’s research focuses on the investigation of co-delivery of the therapeutic agent siRNA, proteins using targeted nanoparticles for the treatment of lung cancer, asthma, COVID-19 and breast cancer. His lab applies interdisciplinary strategies to improve understanding of drugs or nanocarriers’ therapeutic effects. His group is designing a new generation of nanoparticles that could recognize the location of disease cells and selectively deliver drugs and genes to exert therapeutic effects while sparing normal healthy tissues. Ongoing projects include:

  • Targeted inhalation delivery of drugs and siRNA using bio-engineered polymeric or lipidic nanoparticles for the treatment of lung cancer and asthma
  • Multi-target-based combination therapies via natural and bioengineered polymeric systems
  • Tumor-responsive natural and bio-engineered material-based nanocarrier
  • Delivery of Immunomodulatory agents for COVID-19

Chougule Laboratory Website

Teaching Philosophy

My teaching philosophy is to provide student-centered active learning, creative thinking, problem-solving and lifelong interdisciplinary learning skills. The goal of my teaching is to explore many possible ways to mentor pharmacy students, as they become self-directed learners promoting patient-centered health care. My philosophy involves fostering an enjoyable and supportive environment for students learning, conducive to learning skills that will be useful throughout their lifetime. Every student is unique and has his or her own style of learning. I have, therefore, intentionally included a variety of different styles of presenting course material to accommodate students with differing comprehension abilities. I am committed to encouraging lifelong learning for my students and myself. I enjoy interacting with and conveying my passion, knowledge and experience to my pharmacy students.

Awards and Honors

  • The Koichi and Taniyo Taniguchi Award for Excellence and Innovation, 2016
  • 2015 AACR Minority-Serving Institution Faculty Scholar in Cancer Research Award
  • Postdoctoral Research Fellow award, Florida Department of Health, 2010

Selected Patents

  • WO/2008/026044 and WO/2008/129465

Selected Publications

  • PubMed
  • Marathe S., Joshi R., Yang R., Shadambikar G., Bachmann AS., Chougule MB*. Integration of Design of Experiments for the Development and Evaluation of Sulfasalazine Loaded Hybrid Albumin Chitosan Based Polymeric Nanocarriers. AAPS PharmSciTech, 2025 Jul 14;26(6):192.
  • Kashikar, R., Kotha, A. K., Shrestha, R., Channappanavar, R., and Chougule, MB*. Design of experiments using Box-Behnken design in the development, characterization, mathematical modeling, and evaluation of lung-targeted nebulized antiviral camostat mesylate loaded pegylated nanosuspension product. Journal of Drug Delivery Science and Technology, 2024, 98, 105810.
  • Harris HM, Boyet KL, Liu H, Dwivedi R, Ashpole NM, Tandon R, Bidwell GL 3rd, Cheng Z, Fassero LA, Yu CS, Pomin VH, Mitra D, Harrison KA, Dahl E, Gurley BJ, Kotha AK, Chougule MB, Sharp JS*. Safety and Pharmacokinetics of Intranasally Administered Heparin. Pharm Res. 2022 Mar;39(3):541-551.
  • Shadambikar, Marathe S, Ji Nan, Bandari S, Chougule MB, Repka M. Formulation development of itraconazole loaded pegylated nano-lipid carriers for pulmonary aspergillosis using hot melt extrusion technology, International Journal of Pharmaceutics, 2021, Mar 3;3:100074.
  • Chandrasiri I, Abebe DG, Yaddehige ML, Dal Williams JS, Zia MF, Dorris A, Barker A, Vinjamuri, BP, Le N, Gayton JN, Chougule MB, Hammer NI, Flynt A, Delcamp JH, Watkins D. Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications. ACS Applied Bio Materials, 2021, 3(9), 5664-5677.
  • Shahin HI, Vinjamuri BP, Mahmoud AA, Shamma RN, Mansour SM, Ammar HO, Ghorab MM, Chougule MB*, Chablani L. Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension. J Control Release. 2019 Mar 30. pii: S0168-3659(19)30189-0.
  • Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB*. Bioreducible poly (amino ethers) based mTOR siRNA delivery for lung cancer. Pharm Res. 2018 Aug 13;35(10):188.
  • Youngren-Ortiz SR, Hill DB, Hoffmann PR, Morris KR, Barrett EG, Forest MG, Chougule MB*. Development of Optimized, Inhalable, Gemcitabine-loaded gelatin nanocarriers for lung cancer, J Aerosol Med Pulm Drug Deliv. 2017 Mar 9. doi: 10.1089/jamp.2015.1286.
  • España-Serrano L and Chougule MB*. Enhanced anticancer activity of PF-04691502, a dual PI3K/mTOR inhibitor, in combination with VEGF siRNA against non-small cell lung cancer. Molecular Therapy – Nucleic Acids. 2016;5: e384. PMID:27845769.
  • Andey T, Patel A, Marepally S, Chougule M, Spencer S, Rishi AK, Singh M, Formulation, Pharmacokinetic, and efficacy studies of mannosylated self-emulsifying solid dispersions of noscapine. PLoS One. 2016 Jan 12;11(1):e0146804.
  • Chougule MB*, Patel AR, Patlolla R, Jackson T, Singh M. Epithelial transport of Noscapine across cell monolayer and influence of absorption enhancers on in vitro permeation and bioavailability: implications for intestinal absorption. Journal of Drug Targeting. 2014; 22(6):498-508.
  • Patel AR, Chougule MB, Lim E, Francis KP, Safe S, Sachdeva M. Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine. 2014; 10(5):1053-63.
  • Youngren SR, Mulik R, Jun B, Hoffmann PR, Morris KR, Chougule MB*. Freeze-dried targeted mannosylated Selenium-loaded nanoliposomes: development and evaluation. AAPS PharmSciTech. 2013; 14(3):1012-24.
  • Patel AR, Spencer SD, Chougule MB, Safe S, Singh M. Pharmacokinetic evaluation and in vitro-in vivo Correlation (IVIVC) of novel methylene-substituted 3, 3’ diindolylmethane (DIM). European Journal of Pharmaceutical Sciences. 2012; 46(1-2):8-16.
  • Patlolla RR, Chougule MB, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization, and pulmonary deposition of nebulized Celecoxib encapsulated nanostructured lipid carriers. J. of Controlled Release. 2010; 144(2):233-241.
  • Ichite N, Chougule MB, Jackson T, Fulzele S, Safe S, Singh M. Enhancement of Docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clinical Cancer Research. 2009; 15:543-552.
  • Chougule MB, Padhi B, Misra A. Development of spray-dried liposomal dry powder inhaler of Dapsone. AAPSPharmSciTech. 2008; 9(1): 47-53.

Contact Dr. Chougule

Moye Pharmacy and Health Sciences Center #278
(678) 547-6748
chougule_mb@mercer.edu