Dr. Ravi Palaniappan
Associate Professor of Pharmaceutical Sciences
Co-Director of the Vivarium
- B.S., Pharmacy, University of Madras
- M.S., Pharmaceutics, The Tamilnadu Dr. M.G.R. Medical University
- Ph.D., Pharmaceutics, University of Madras
Research Background and Interests
Dr. Palaniappan currently manages the Mucosal Proteomics lab with special emphasis on vaccine formulations for prostate cancer vaccine and pneumonia protein vaccines in collaboration with CDC, Emory and UAB.
Pneumonia vaccine formulation: PsaA and PspC protein vaccines which are developed by CDC and UAB (Under Phase I clinical trial now) are formulated using microspheres for oral vaccines. Dr. Ravi has been funded by the NIH to formulate this oral vaccines and to study the mucosal immune response and adjuvant effects of microspheres.
Anthrax antibody formulation development: The major goals of this project are to develop methods of generating passive mucosal and systemic immunity to Bacillus anthracis exotoxins (lethal toxin (LeTx) and edema toxin (EdTx)) by administering monoclonal antibodies (mAbs) to protective antigen (PA). Particular emphasis will be directed to the use of novel microspheres (and nanospheres) for oral delivery of anti-PA mAbs for anthrax exotoxin prophylactic and therapeutic treatments.
Prostate cancer vaccine targeted delivery using natural polymeric nano particles: Tumors modified by transfecting genes for immunostimulatory molecules such as B7 and cytokines are now considered as a potential therapeutic tumor vaccine. However, transfection is not always efficient and can be difficult with many cell types, especially freshly isolated tumor cells from patients. Moreover, transfection of genes requires the introduction of vectors of viral origin which is not desirable for human therapeutic purposes. Studies have shown that purified GPI-anchored cell surface proteins can be spontaneously incorporated into membranes by incubating the proteins with the cells or cell membranes (Protein Transfer). This unique property can be used to reconstitute cell surface expression receptors on cell membranes without the use of gene transfection. Using recombinant techniques, our collaborator has developed many immunostimulatory molecules including B7-1, IL-2, GM-CSF and IL-12 as GPI-anchored form. Currently we are using protein transfer to express these molecules to develop cancer vaccines for prostate cancer and melanoma. These vaccines will be formulated into nano particle for targeting to prostate cancer sites.
- PHA 325 Principles of Pharmaceutical Sciences
- PHA 807 Pharmaceutical Biotechnology
- PHA 836 Advanced Physical Pharmacy II
- PHA 899 Doctoral Research
- Palaniappan, R., Singh, S., Singh, R., Singh, E.W., Ades, D.E., Briles, S.K., Hollingshead, W., Royal, III, J.S., Sampson, J.K., Stiles, D.D., Taub, and J.W. Lillard, Jr. “CCL5 Modulates Pneumococcal Immunity and Carriage1.” The Journal of Immunology, 176, (2006) 2346-2356.
Contact Dr. Ravi Palaniappan